

Quest Plus(R) Gel (moxidecin/praziquantel) Combines 2% moxidectin and 12.5% praziquantel for the treatment and control of large and small strongyles, encysted cyathostomes, ascarids, pinworms, hairworms, large mouth stomach worms, stomach bots and tapeworms. One dose also suppresses strongyle egg production through 84 days. May be used in horses and ponies 6 months of age and older. Testing has not been done in breeding mares or stallions. Each sure-dial syringe is calibrated in 50 lb. increments, and treats up to 1,150 lbs. body weight. FOR ORAL USE IN HORSES AND PONIES SIX MONTHS OF AGE AND OLDER INDICATIONS : QUEST PLUS (moxidectin/praziquantel) Equine Oral Gel when administered at the recommended dose level of 0.4 mg moxidectin/kg and 2.5 mg praziquantel/kg (2.2 lb) body weight is effective in the treatment and control of the following stages of gastrointestinal parasites in horses and ponies: Large Strongyles, Small Strongyles, Encysted cyathostomes, Ascarids, Pinworms, Hairworms, Large-mouth stomach worms, Horse stomach bots, Tapeworms. One administration of the recommended dose rate of QUEST PLUS (moxidectin/praziquantel) Equine Oral Gel also suppresses strongyle egg production through 84 days. STRATEGIC PROTECTION PROGRAMS : Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. For best control of parasites, all horses and ponies should be included in a strategic treatment program, with particular attention given to high performance animals. In foals, initial treatment is recommended at 6 months of age, after which they should be included in a recurrent treatment program. Because QUEST PLUS provides effective control of the mucosal stages of small strongyles (encysted cyathostomes) and tapeworms, it is useful in reducing the frequency of treatment required for successful strategic equine parasite control. A veterinarian can assist in preparing the best program for your needs. QUEST PLUS Equine Oral Gel when used at the recommended dose rate suppresses strongyle egg production through 84 days following a single oral administration. This residual strongyle control reduces pasture contamination and provides a period of protection from reinfection for horses and ponies maintained on the same pasture. MODE OF ACTION : QUEST PLUS Equine Oral Gel contains two active pharmaceutical ingredients, moxidectin and praziquantel. Moxidectin acts by interfering with chloride channel-mediated neurotransmission in the parasite. This results in paralysis and elimination of the parasite. Moxidectin is safe for use in horses and ponies because it does not have the same injurious effect on the mammalian nervous system. Praziquantel increases the tapeworm’s membrane permeability to calcium and other cations causing severe contraction and paralysis of the tapeworm’s muscles. This spastic paralysis results in the inability of tapeworms to attach to the host’s intestinal wall. Detached tapeworms are either destroyed
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